She is on a constant low dose of Baytril (antibiotic) because the majority of her issues seem to stem from infection. Without antibiotics, she gets chronic UTIs, which make her appear uncomfortable. This keeps the bacterial load under control. We also have the option to put her an an antiinflammatory should she show signs of interstitial cystitis or bladder wall thickening/irritation, but thus far she has been doing fine on the antibiotic. Really, her only symptom has been chronic UTIs which are under control with the meds. She has never been off her food or needed supportive feeding because of her bladder (she has been on Critical Care by syringe due to a huge facial abscess a couple of years ago, but that was an entirely separate problem, and she beat that too because she is such a trooper!) I also had very mixed feelings about treating conservatively, because I've also often heard that the only options are euthanasia or surgical removal, but ultimately I'm very pleased with how things have gone for her. She has never appeared to be in pain (and I know that guinea pigs hide it well, but having seen her with a big facial abscess I could clearly tell that she was not herself and uncomfortable with that. She has never shown those signs from her bladder issues.) I also think that some guinea pigs are just more resilient than others. My vet has said the same... that a lot of guinea pigs don't pull through because they simply don't cope well with any pain or discomfort and refuse to eat and basically shut down physically due to the shock or stress. One of my other pigs, Linney, was a massive wimp when it came to pain- once I rushed her to the vet thinking she had a stroke because she didn't appear able to walk... turned out she had a UTI. Apparently the discomfort was such that she decided she would just lay stretched out, refuse to eat, and roll from side to side! We treated it and she was fine, but it really brought home the difference in pain/illness tolerances between different individuals! My vet recently said that Sundae must have the heart of a much tougher animal in a little tiny body, as she has thrived in spite of a bladder stone and a really nasty abscess in her jaw... she is a tough girl!