My girls have fleece over towels; ours are sized to fit their cages. They work quite well. We change and wash them every few days. They have two full sets of liners each, and then we have some extra towels and a small pile of fleece waiting to be turned into liners; laundry goes through often enough to make the two sets work, though.
Make sure you wash your fleece thoroughly to get any sizing out, or liquid will bead on top instead of wicking through. Once you've done that, it works great ... the fleece will stay nice and dry on top and fluids will go through to the towel(s).
We use unprinted newsprint as our bottom layer, so:
newsprint -> towel -> fleece -> guinea pig!
When we change the cage, we shake the debris on top of the liners onto the newsprint or into a bag, rubbing the liner against itself helps get a lot of the hair and hay off ... make sure to knock off all the poos. The liners then get set aide to be washed; the (dry) fleece gets shaken outside before going into the washer to release remaining hay bits (and poos); the towel gets rechecked for poos ... especially Latte's, since she'll flip up the fleece, poo underneath and then put the fleece back,

. The newsprint (which is often missing pieces that have been ripped up by piggies ...) gets scooped up with the debris and tossed, then the cage can be wiped down (and/or scraped for those piggies that like to poo/piddle under the corners of the liner ... Latte, I'm looking at you) and reset.
Pretty simple ... simpler than litter, just about twice as frequent. Fleece we change every few days; Carefresh lasted about a week.