Is your guinea pig acting any differently to normal? Piggies tend to hide sickness well due to being prey animals. If you are at all concerned take your piggie to a vet for a diagnosis.
Any changes in normal behaviour, lethargy, lack of appetite etc. Weight loss always tends to be the case with ill piggies too - hence why you should regularly weigh them.
As said above, any concerns definitely warrants a vet check up.
If you suspect a piggy is ill, then you switch from the routine weekly weight checks and instead weigh them daily. This enables you to step in and syringe feed to stop further weight loss and ensure the gut continues to function while you wait for your vet appointment.
Otherwise, as prey animals, they hide their illnesses so any change in normal behaviour can be a sign they aren't feeling well.
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