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Please help with figuringout ongoing health issue

mrs megumi

Junior Guinea Pig
Joined
Aug 8, 2025
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Hi!
I would like to ask if anyone has experienced a similar health problem in guinea pigs, as despite many visits to a very knowledgeable exotic vet we have not solved the problem. This concerns my female guinea pig, currently 4.5 years old. She has been neutered almost 2 years ago due to ovarian cysts. (NOTE! Graphic description of the problem follows: )
The problems we have now started earlier this year in February and what happens is blood-colored mucus comes from her anal opening from time to time. Sometimes it is dark red, and sometimes it is just light, light pink. I would describe it as slime that I sometimes find on her, sometimes on the blanket she has been sitting on, etc. This has been going on since February, it does not come very often, sometimes several weeks go by without me seeing it. About 2 times I have seen that she seems to be in pain when she poops, then there has also been a little blood on the poop that I can see when I put it on kitchen paper. Otherwise, her general condition is very good, she behaves and eats as usual, even her poop looks healthy. She has not lost any weight. She has been to the vet on several occasions for these problems. In March she underwent surgery for this, after an ultrasound we thought it was a tumor in the urine bladder, but during the surgery nothing was found and all the organs looked, according to the vet, good. The bladder was never opened because it looked healthy and she could have had other problems after such an operation.

After the surgery, the vet no longer believes it is a tumor of some kind, and if it had been, we would have very likely seen more/increased symptoms now 6 months later. In June, her stool was sent for testing, but no, they couldn't find anything strange there. Her diet consists of hay and vegetables and right now I'm logging all the vegetables she gets, to try to piece together any symptoms. So I'm trying to see if she is sensitive to any particular vegetable and that is what causes this blood-mixed mucus to form. But she eats basically the same kind of vegetables that she also ate before all this started, so this also feels a bit far-fetched. I buy my hay from the same place as before.
Has anyone experienced anything similar? It feels like we've hit a dead end and it pains me that my little darling is not feeling quite well and may also be in pain now and then.
Thanks in advance! Appreciate any help!
Not sure how to post photos here, if you want to see photos of the mucus please go to this sweidsh forum for guinea pigs where I posted the same question: Önskar hjälp med att lösa långdraget hälsomysterium | Marsvin iFokus
 
Hello and welcome to the forum. I don’t have any experience of this. Hopefully someone will be along soon with advice.
 
It might be worth asking your vet if you could trial a course of Sulfasalazine, it helps with GI inflammation. I had one on it for a while as she was passing very mucoussy poops, occasionally with some blood. It seemed to help although her issues were due to inability to absorb nutrition properly from nerve issues in the spine rather than a GI issue so it didn't fix things entirely.
 
It might be worth asking your vet if you could trial a course of Sulfasalazine, it helps with GI inflammation. I had one on it for a while as she was passing very mucoussy poops, occasionally with some blood. It seemed to help although her issues were due to inability to absorb nutrition properly from nerve issues in the spine rather than a GI issue so it didn't fix things entirely.
Thank you, I will discuss this with my vet as soon as possible!
 
Thank you, I will discuss this with my vet as soon as possible!
How did you get on with your little one?
I could have written your post - I posted a similar one today. My girl has reddish mucus poops which are soft, today and previously I’ve noticed now and then.
Fine in herself but squeaking when pooping. Going to the vet tomorrow 😥
 
How did you get on with your little one?
I could have written your post - I posted a similar one today. My girl has reddish mucus poops which are soft, today and previously I’ve noticed now and then.
Fine in herself but squeaking when pooping. Going to the vet tomorrow 😥
Hi there! Thank you for commenting. I'm afraid I don't have any news to share yet, I've just been tracking her intake of veggies but quite honestly I don't think they are the cause. My vet has been on holiday, right now I'm waiting for her to give me a call so we can talk about the plan forward. In the meantime I'm also going to try having her on Recovery Plus luquid feed only as my vet suggested (and hay and water of course) and see if that makes any differnece.
What did your vet say? I hope we can keep in touch, I really want to go to the bottom of this. My girl has had reddish slime today and also squekead when pooping :-(
 
Hi there! Thank you for commenting. I'm afraid I don't have any news to share yet, I've just been tracking her intake of veggies but quite honestly I don't think they are the cause. My vet has been on holiday, right now I'm waiting for her to give me a call so we can talk about the plan forward. In the meantime I'm also going to try having her on Recovery Plus luquid feed only as my vet suggested (and hay and water of course) and see if that makes any differnece.
What did your vet say? I hope we can keep in touch, I really want to go to the bottom of this. My girl has had reddish slime today and also squekead when pooping :-(
Hiya no problem at all, they are complex little animals aren’t they.
She went down in weight over the weekend but I’m hoping that’s because of the stress of the vets. I didn’t have time before work today to weigh her so I’ll do it tonight and pray she hasn’t lost more.
She’s happy in herself. Didn’t squeak for 3 days and suddenly heard her last night :(
It’s strange sometimes the mucus is clear sometimes red.

So my vet said very possibly interstitial cystitis as she’s showing no other symptoms.
If weight loss continues she will do an X-ray / scan.

I’ve got metacam (dog) and some gabapentin which I haven’t touched yet as want to see how she goes on the metacam first as the other one can make them very spaced out and drowsy.

Ruby is the most nervous guinea pig I’ve had, not sure about your little one?
But it’s a very common problem in super nervous piggy’s. At least we think it’s that, time will tell
I’ve also bought some feliway cystease to help her bladder lining.
Someone on here recommended it on my other post x
 
Hiya no problem at all, they are complex little animals aren’t they.
She went down in weight over the weekend but I’m hoping that’s because of the stress of the vets. I didn’t have time before work today to weigh her so I’ll do it tonight and pray she hasn’t lost more.
She’s happy in herself. Didn’t squeak for 3 days and suddenly heard her last night :(
It’s strange sometimes the mucus is clear sometimes red.

So my vet said very possibly interstitial cystitis as she’s showing no other symptoms.
If weight loss continues she will do an X-ray / scan.

I’ve got metacam (dog) and some gabapentin which I haven’t touched yet as want to see how she goes on the metacam first as the other one can make them very spaced out and drowsy.

Ruby is the most nervous guinea pig I’ve had, not sure about your little one?
But it’s a very common problem in super nervous piggy’s. At least we think it’s that, time will tell
I’ve also bought some feliway cystease to help her bladder lining.
Someone on here recommended it on my other post x
Oh and her poops have firmed up, but on and off softer than usual. They have never really been ‘normal’
I give fibreplex for rabbits twice a day now, leave it in the cage on a small lid and she loves it. Eats it when she wants then
 
I just wanted to say that just because a guinea pig's diet hasn't changed doesn't mean that it's impossible for some specific veggie to be the culprit. Sometimes their systems get more sensitive as they get older and they get some irritation from foods that used to be fine. A couple of my older ladies I've had to stop giving cucumber or give it a lot less often because it started to give them soft stools or slight gassiness even though they loved it as babies.
 
I just wanted to say that just because a guinea pig's diet hasn't changed doesn't mean that it's impossible for some specific veggie to be the culprit. Sometimes their systems get more sensitive as they get older and they get some irritation from foods that used to be fine. A couple of my older ladies I've had to stop giving cucumber or give it a lot less often because it started to give them soft stools or slight gassiness even though they loved it as babies.
I miss totally agree. My older piggies in the past have had tummy issues with food as they’ve gotten older, need to be so careful.
I stupidly gave her green beans and strawberry as a one off in one evening and that really upset her belly.
 
Here´s a bit of an update! For almost 4 full weeks now my guinea pig has been completly off vegetables - she is getting her daily c-vitamin through either recovery plus (liquid feed) or C-vitamin drops (especially for guinea pigs). She has improved! Last time I saw blood/mucus in her poo or that it was painful for her to poop was the second day of this new diet - so veggies was probably still in her system/inflammation in her gut was not healed yet.
I will keep her on this diet for another 4 weeks before doing an evaluation together with my vet. In the end I'm hoping we eventually can go back to give her some veggies but will have to wait and see. Worst case scenario I guess she has to stay on this diet of hay, water and recovery plus/c-vitamin drops.
 
Here´s a bit of an update! For almost 4 full weeks now my guinea pig has been completly off vegetables - she is getting her daily c-vitamin through either recovery plus (liquid feed) or C-vitamin drops (especially for guinea pigs). She has improved! Last time I saw blood/mucus in her poo or that it was painful for her to poop was the second day of this new diet - so veggies was probably still in her system/inflammation in her gut was not healed yet.
I will keep her on this diet for another 4 weeks before doing an evaluation together with my vet. In the end I'm hoping we eventually can go back to give her some veggies but will have to wait and see. Worst case scenario I guess she has to stay on this diet of hay, water and recovery plus/c-vitamin drops.
Oh wow very interesting! I literally read another ladies post on Facebook who said she has to do the same thing, stop all veggies as it just upset her piggies tummy so much.
Maybe something I should try 🤔
 
Oh wow very interesting! I literally read another ladies post on Facebook who said she has to do the same thing, stop all veggies as it just upset her piggies tummy so much.
Maybe something I should try 🤔
Is you girl still having problems with mucus/blood or is she doing better?
 
Is you girl still having problems with mucus/blood or is she doing better?
I’ve seen a bit of mucus yesterday in her poop, first that I’ve noticed for a while.
I stopped her wheatgrass since I found out it’s really high in calcium, I was feeding it twice / 3 times a day.

I think she seems a little better since, and I’ve been giving her fibreplex daily which seems to have helped.

Though she lost a bit more weight a few days ago since I stopped the fibreplex.
I’m putting her back in it, seeing if that helps
I’ve not actually heard her cry for a few days now, but I’ve been working 12 hour days so not spent a ton of time with her.

Home tomorrow all day so will see how she goes 😬
 
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