Mine have walk-in cages, so they don't get handled quite as often. I also have my cuddle piggies who like a smooch and those who simply don't enjoy it and who I only health check once weekly. My piggies' main focus is the group they live in and having a happy piggy life rather than a cuddly pet life, but I take care that they are comfortable enough with being handled to not freak out on vet trips.
How often you want to pick up your piggies is up to you. If you have shy, nervous piggies or those that really don't like human contact, I would recommend to go slowly at first.